LennernÃ¤s, Hans: search on Z-Library

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1

Pharmacodynamics and Pharmacokinetics of the HMG-CoA Reductase Inhibitors

Dr Hans Lennernäs, Gunnar Fager

Journal:

Clinical Pharmacokinetics

Year:

1997

Language:

english

File:

PDF, 3.60 MB

english, 1997

2

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David, Lennernäs, Hans

Journal:

Year:

2019

Language:

english

File:

PDF, 1.34 MB

english, 2019

3

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna, ThÃ¶rn, Helena, LennernÃ¤s, Hans, SjÃ¶gren, Erik

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2020

File:

PDF, 1.60 MB

2020

4

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation ofin VitroDrug Product Dissolution andin VivoBioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah, John R. Crison

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.34 MB

1995

5

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Johannsson, Gudmundur, Falorni, Alberto, Skrtic, Stanko, Lennernäs, Hans, Quinkler, Marcus, Monson, John P., Stewart, Paul M.

Journal:

Clinical Endocrinology

Year:

2015

Language:

english

File:

PDF, 295 KB

english, 2015

6

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || High-Throughput Measurement of log D and pKa

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 372 KB

english, 2003

7

The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids

Eva M. Persson, Ann-Sofie Gustafsson, Anders S. Carlsson, Ralf G. Nilsson, Lars Knutson, Patrick Forsell, Gunilla Hanisch, Hans Lennernäs, Bertil Abrahamsson

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 484 KB

english, 2005

8

Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

Tannergren, Christer, Bergendal, Anna, Lennernäs, Hans, Abrahamsson, Bertil

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

9

The BCS, BDDCS, and Regulatory Guidances

Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas, Lawrence X. Yu

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 124 KB

english, 2011

10

Comparison Between Permeability Coefficients in Rat and Human Jejunum

Urban Fagerholm, Monica Johansson, Hans Lennernäs

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.11 MB

1996

11

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Year:

2020

File:

PDF, 1.27 MB

2020

12

Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Lennernäs, Hans, Skrtic, Stanko, Johannsson, Gudmundur

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2008

Language:

english

File:

PDF, 272 KB

english, 2008

13

Modeling Gastrointestinal Drug Absorption Requires More In Vivo Biopharmaceutical Data: Experience from In Vivo Dissolution and Permeability Studies in Humans

Lennernas, Hans

Journal:

Current Drug Metabolism

Year:

2007

Language:

english

File:

PDF, 410 KB

english, 2007

14

Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids

Betty Lomstein Pedersen, Helle Brøndsted, Hans Lennernäs, Finn Norring Christensen, Anette Müllertz, Henning Gjelstrup Kristensen

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 151 KB

english, 2000

15

A comparison between direct determination of in vivo dissolution and the deconvolution technique in humans

Lisbet Bønløkke, Lars Hovgaard, Henning G. Kristensen, Lars Knutson, Anders Lindahl, Hans Lennernäs

Journal:

European Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 215 KB

english, 1999

16

Regional intestinal drug permeation: Biopharmaceutics and drug development

Lennernäs, Hans

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 862 KB

english, 2014

17

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik, Dahlgren, David, Roos, Carl, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 1023 KB

english, 2015

18

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

Hans Lennernäs, Bertil Abrahamsson

Journal:

Journal of Pharmacy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 212 KB

english, 2005

19

Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Winiwarter, Susanne, Bonham, Nicholas M., Ax, Fredrik, Hallberg, Anders, Lennernäs, Hans, Karlén, Anders

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 179 KB

english, 1998

20

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Cell Cultures in Drug Discovery: An Industrial Perspective

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 344 KB

english, 2003

21

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Dahan, Arik, Miller, Jonathan M., Hilfinger, John M., Yamashita, Shinji, Yu, Lawrence X., Lennernäs, Hans, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 552 KB

english, 2010

22

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs

David, Dahlgren, Carl, Roos, Pernilla, Johansson, Christer, Tannergren, Anders, Lundqvist, Peter, Langguth, Markus, Sjöblom, Erik, Sjögren, Hans, Lennernäs

Journal:

International Journal of Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.55 MB

english, 2018

23

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David, Roos, Carl, Lundqvist, Anders, Abrahamsson, Bertil, Tannergren, Christer, Hellström, Per M., Sjögren, Erik, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2016

Language:

english

File:

PDF, 958 KB

english, 2016

24

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David, Roos, Carl, Johansson, Pernilla, Lundqvist, Anders, Tannergren, Christer, Abrahamsson, Bertil, Sjögren, Erik, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

25

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie, Sjögren, Erik, Hansson, Per, Lennernäs, Hans

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

26

Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability

Susanne Winiwarter, Fredrik Ax, Hans Lennernäs, Anders Hallberg, Curt Pettersson, Anders Karlén

Journal:

Journal of Molecular Graphics and Modelling

Year:

2003

Language:

english

File:

PDF, 543 KB

english, 2003

27

Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

Malm-Erjefält, Monika, Ekblom, Marianne, Vouis, Jan, Zdravkovic, Milan, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 2.21 MB

english, 2015

28

Chitosans as absorption enhancers of poorly absorbable drugs: 3: Influence of mucus on absorption enhancement

Nicolaas G.M. Schipper, Kjell M. Vårum, Patric Stenberg, Göran Ocklind, Hans Lennernäs, Per Artursson

Journal:

European Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 430 KB

english, 1999

29

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 755 KB

english, 2014

30

The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Selen, Arzu, Dickinson, Paul A., Müllertz, Anette, Crison, John R., Mistry, Hitesh B., Cruañes, Maria T., Martinez, Marilyn N., Lennernäs, Hans, Wigal, Tim L., Swinney, David C., Polli, James E., Sera

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 723 KB

english, 2014

31

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik, Westergren, Jan, Grant, Iain, Hanisch, Gunilla, Lindfors, Lennart, Lennernäs, Hans, Abrahamsson, Bertil, Tannergren, Christer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 2.63 MB

english, 2013

32

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik, Tammela, Teuvo L., Lennernäs, Bo, Taari, Kimmo, Isotalo, Taina, Malmsten, Lars-Åke, Axén, Niklas, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 6.04 MB

english, 2014

33

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Application of the Biopharmaceutic Classification System Now and in the Future

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 742 KB

english, 2003

34

Pulmonary dissolution of poorly soluble compounds studied in an ex vivo rat lung model

Eriksson, Johanna, Thörn, Helena, Sjögren, Erik, Holmstén, Lisa, Rubin, Katarina, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2019

Language:

english

File:

PDF, 1.42 MB

english, 2019

35

Clinical Pharmacokinetics of Atorvastatin

Professor Hans Lennernäs

Journal:

Clinical Pharmacokinetics

Year:

2003

Language:

english

File:

PDF, 204 KB

english, 2003

36

Pulmonary absorption rate and bioavailability of drugs in vivo in rats: Structure–absorption relationships and physicochemical profiling of inhaled drugs

Ann Tronde, Bo Nordén, Hans Marchner, Anna-Karin Wendel, Hans Lennernäs, Ursula Hultkvist Bengtsson

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 378 KB

english, 2003

37

Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC–MS/MS) of ximelagatran and its metabolites in a complex matrix

Björn Arvidsson, Erik Allard, Erik Sjögren, Hans Lennernäs, Per Johan Ragnar Sjöberg, Jonas Bergquist

Journal:

Journal of Chromatography B

Year:

2009

Language:

english

File:

PDF, 347 KB

english, 2009

38

Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of Administration

Eva Bredberg, Hans Lennernäs, Lennart Paalzow

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 1.27 MB

1994

39

Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract

Eva Krondahl, Ann Tronde, Stefan Eirefelt, Heidi Forsmo-Bruce, Gunilla Ekström, Ursula Hultkvist Bengtsson, Hans Lennernäs

Journal:

Year:

2002

Language:

english

File:

PDF, 109 KB

english, 2002

40

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Aqueous Solubility in Discovery, Chemistry, and Assay Changes

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

41

Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine

Narushi Takamatsu, Ok-Nam Kim, Lynda S. Welage, Nasir M. Idkaidek, Yayoi Hayashi, Jeffrey Barnett, Ryuzo Yamamoto, Elke Lipka, Hans Lennernäs, Ajaz Hussain, Lawrence Lesko, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

42

Regional Jejunal Perfusion, a Newin VivoApproach to Study Oral Drug Absorption in Man

Hans Lennernäs, Örjan Ahrenstedt, Roger Hällgren, Lars Knutson, Märta Ryde, Lennart K. Paalzow

Journal:

Pharmaceutical Research

Year:

1992

File:

PDF, 1.67 MB

1992

43

The pharmacokinetics and metabolism of α-trinositol (d-myo-inositol 1,2,6-trisphosphate): Studies involving intravenous infusion in rats, metabolism in human platelets and leukocytes, and dephosphorylation by bovine alkaline phosphatases

Hans Lennernäs, Thomas Lundqvist, Kalwant S. Authi, Anneli Lindahl, Sinikka Okkola, Torgny O. Gustafsson

Journal:

European Journal of Pharmaceutical Sciences

Year:

1997

Language:

english

File:

PDF, 378 KB

english, 1997

44

Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba, Matsson, Elin M., Hedeland, Mikael, Bondesson, Ulf, Knutson, Lars, Lennernäs, Hans

Journal:

Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 455 KB

english, 2010

45

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Front Matter

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 120 KB

english, 2003

46

Evidence for an Interaction Between the β-Blocker Pafenolol and Bile Salts in the Intestinal Lumen of the Rat Leading to Dose-Dependent Oral Absorption and Double Peaks in the Plasma Concentration–Time Profile

Hans Lennernäs, Carl-Gunnar Regårdh

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 1001 KB

1993

47

Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

Eve-Irene Lepist, Tina Kusk, Dorrit H Larsen, Dorthe Andersen, Sven Frokjaer, Mitchell E Taub, Peep Veski, Hans Lennernäs, Gerda Friedrichsen, Bente Steffansen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000

48

The Pharmacokinetics and Hepatic Disposition of Repaglinide in Pigs: Mechanistic Modeling of Metabolism and Transport

Sjögren, Erik, Bredberg, Ulf, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 1.56 MB

english, 2012

49

Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

Thörn, Helena Anna, Yasin, Mohammed, Dickinson, Paul Alfred, Lennernäs, Hans

Journal:

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

50

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || VOLSURF: A Tool for Drug ADME-Properties Prediction

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 728 KB

english, 2003

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